Synthesis and biological evaluation of ebselen and its acyclic derivatives.
نویسندگان
چکیده
Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 51 12 شماره
صفحات -
تاریخ انتشار 2003